weight loss zonisamide |
weight loss zonisamide
Zonisamide is a unique drug that affects the excitatory neurotransmitter glutamate, thereby causing a reduction in the glutamatergic transmission of input from the sensory cortex. This results in decreased neuronal activity and an initial reduction in food intake, which is maintained by a reduction in the number of eating episodes.
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Zonisamide is a novel anticonvulsant drug whose pharmacological activity was first described in the early 1980s. It inhibits GABAergic transmission by a competitive but non-selective action as an antagonist at the [4-aminopyridine (4-AP)-sensitive] (GABA-A) channel, with a high affinity for the alpha4 subunit and also a lesser affinity for alpha2 and alpha3 subunits. It has also been suggested that zonisamide may modulate AMPA-mediated responses, but the precise mechanism of this action is unknown, though it may involve ion channel inhibition or modulation of the activity of second-messenger dependent intracellular protein(s) such as Ca2+, calmed
Zonisamide, or (RS)-5-hydroxy-1-(4-oxo-2-thiazolyl)benzimidazole-2-sulfonamide, is a sulfamoylbenzoate derivative of a benzimidazole. The medication is used for the treatment of epilepsy and depression. Zonisamide has neuroprotective and anticonvulsant properties in preclinical models. Zonisamide also exhibits neuroregenerativie
Zonisamide is a medication used for the treatment of partial seizures and generalized tonic-clonic seizures. Zonisamide is a benzisoxazole derivative of zonisamide, a substance derived from the fungus (Bolton, 1997). Zonisamide has been in human clinical trials since the 1990s.
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